Typhonium flagelliforme extract and other herbs combine help in the detoxification of the blood system. Typhonium flagelliforme is a species of flowering plant in the family araceae typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh, bhutan. One to five small blue green leaves appear flat against the ground following flowering. Rodent tuber typhonium flagelliforme lodd blume is one of the medicinal plants used for anticancer treatment, but the information on the cultivation of the plant is limited. Dries damp, transforms phlegm, expels wind, and stops spasms for windstroke conditions, tremors, convulsions, facial paralysis, hemiplegia, bells palsy, epilepsy, tetanus, and migraines eliminates toxicity and dissipates toxicity for scrofula, snake bites, and other nodules due to phlegm and toxicity. This plant had shown to induce antiproliferative effect. Nevertheless, it is a rarely seen plant in cultivation and not often seen in collections. A bioassay guided approach was used to isolate photosensitizing compounds from typhonium flagelliforme schott, a plant considered by local communities to possess anticancer properties.
Typhonium giganteum herb uses, benefits, cures, side effects. Typhonium flagelliforme inhibits the proliferation of. Blume, commonly known as rodent tuber in malaysia, is one of the widely used alternative medicines in cancer therapy by south east asian population. Reports about adverse effects from dietary supplements for weight loss that contain ephedrine have been appearing for more than a decade. Files are available under licenses specified on their description page. Intake of this plant is common among patients with malignancies. Pdf antibacterial and antioxidant activity of keladi tikus. Cytotoxicity effects of typhonium flagelliforme and clinacanthus nutans on breast cancer cells. K ras is an oncogenic gtpase responsible for at least 1525% of all nonsmall cell lung cancer cases worldwide. Female flowers 1loculed with 1 or 2or 3 orthotropous basal ovules. Abstractobjectiveto determine the inhibition activity of typhonium flagelliforme lodd. Typhonium flagelliforme antiproliferation activity, while interferons ifns one of the cytokines that first used as an antiviral agent was also known to have antitumor activity. The hexane extract from typhonium flagelliforme tuber had interesting activity against both the gram negative.
Blume araceae is a malaysian plant used locally to combat cancer. Two putative photosensitizers, pbeophorbidea and a possible novel derivative, 2, 17dihydroxyethyl pheophorhidea were isolated using column chromatography and purified on thin layer. It has an oblong whitish tuber, triangular leaves ad a spathe. The plant list includes 115 scientific plant names of species rank for the genus typhonium.
Names of typhonium giganteum in various languages of the world are also given. Cytotoxic activity of typhonium flagelliforme araceae. This study aims to determine the antibacterial and antioxidant activity of different extracts of leaves t. Antibacterial and antioxidant activity of keladi tikus leaves extract. In vitro anticancer activity was assayed by mtt method on widr colon cancer cells. Characterisation of two photosensitizing compounds from. List of various diseases cured by typhonium giganteum. Chemical ingredients were identified as methyl esters of hexadecanoic acid, octadecanoic acid, 9octadecenoic acid and 9,12 octadecadienoic acid. These supplement products were developed from research indicating that ephedrine, a naturallyoccurring compound mainly found in species of ephedra, behaves much like the drugs amphetamine and dexamphetamine dexedrine, used to stimulate energy, reduce.
Micropropagation of rodent tuber typhonium flagelliforme lodd. Typhonium flagelliforme, previously mistakenly referred as typhonium divaricatum nicolson and sivadasan, 1981, is commonly known as rodent tuber in malaysia. Typhonium flagelliforme is currently being investigated for its cancer curing properties and has long been used as a traditional medicine in parts of asia. Edp 50 values of the hexane fractions of the mature plant and thein vitro plantlet oft. All structured data from the file and property namespaces is available under the creative commons cc0 license. Rodent tuber grows wild in wasteland and is native to the south east asian countries. Typhonium praetermissum is a perennial herb with aerial parts emerging annually from a bulbous corm. This page was last edited on 8 december 2019, at 15. This plant grows wild in wasteland and is native to the south east asian countries. We do not intend the plant list to be complete for names of infraspecific rank. In vitro culture plants of typhonium flagelliforme were found to decolorize a variety of dyes, including malachite green, red he 8b, methyl. Typhonium flagelliforme, phytochemicals, traditional medicine. Antileukemic effects of typhonium flagelliforme on human.
Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis an evaluation. In vitro propagation of typhonium flagelliforme lodd blume. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs. Antibacterial and antioxidant activity of keladi tikus leaves. These are primarily included because names of species rank are. Nowadays, the treatment of tumors using a traditional way, including the use of herbal substances, becomes popular.
The plant list includes a further 14 scientific plant names of infraspecific rank for the genus typhonium. Blume is guess contains flavonoid compounds as dihidroflavonol groups, flavon, isoflavon and auron key words. Ingredients typhonium plus alternative cancer treatment. Typhonium flagelliforme is a species of flowering plant in the family araceae. Studies on phytoremediation potentiality of typhonium flagelliforme.
Typhonium flagelliforme tf is a tropical plant, traditionally used by the ethnic population of malaysia for the cure of various cancers. Fraction from typhonium flagelliforme tuber citeseerx. Analysis of preliminary phytochemical screening of typhonium. To date, there has been no literature reported on the mechanism of typhonium flagelliforme and its effects on leukemia. Typhonium flagelliforme is a medicinal herb which belongs to the araceae arum family. It is now grown in many malaysian and s ingaporean household gardens for its medicinal value. The hexane extract was reported to contain saturated hydrocarbons and aliphatic acids 7, while the ethyl. The effects of gamma irradiation on growth response of. A cerebroside, with significant antihepatotoxic activity and phenylpropanoid glycosides isolated from flagelliforme typhyonium for the first time huang et al.
To determine the inhibition activity of typhonium flagelliforme lodd. Typhonium flagelliforme induces apoptosis in cemss cells via. Celecoxib, a selective cox2 inhibitor, was used as a positive control. The objectives of this research was to study the effect of light intensity and concentration level. Conventional treatments have been used to treat cancer. Typhonium flagelliforme is a species of flowering plant in the family araceae typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh, bhutan, cambodia, india, indonesia, laos, malaysia, myanmar, philippines, singapore, sri lanka, thailand, new guinea, queensland, and the australian northern territory references. Lung cancer of both types is increasing with an alarming rate due to smoking habits in malaysia among men and women. Download fulltext pdf download fulltext pdf antibacterial and antioxidant activity of keladi tikus leaves extract typhonium flagelliforme lodd blume article pdf available december 2014. Typhonium flagelliforme from the fam ily araceae is locally known as rodent tuber. Two putative photosensitizers, pbeophorbidea and a possible novel derivative, 2, 17dihydroxyethyl pheophorhidea were isolated using column chromatography. Pdf typhonium flagelliforme inhibits cancer cell growth. The effects of gamma irradiation on growth response of rodent.
Keladi tikus rodent tuber typhonium flagelliforme lood bl. The board of trustees of the royal botanic gardens, kew. The major aim of this study was to investigate the effect of typhonium flagelliforme crude extract on hepatocarcinogenesis in rats induced by. Pdf antibacterial and antioxidant activity of keladi. Extraction and fractionation using organic solvents were applied to obtain fractions from t. Jan 01, 2001 the plant typhonium flagelliforme araceae, commonly known as the rodent tuber, is often included as an essential ingredient in various herbal remedies recommended for cancer therapies in malaysia. The plant typhonium flagelliforme, commonly known as rodent tuber in malaysia, is often used as a health supplement and traditional remedy. Being described ethnomedically as toxic, warming and phlegm resolving, this plant is used to soothe swelling, coughing and more predominantly for the treatment of cancer teo and ch. Here, we investigated in vitro and in vivo effects. Introduction typhonium flagelliforme is a medicinal herb which belongs to the araceae arum family. Typhonium giganteum herb uses, benefits, cures, side. Keladi tikus typhonium flagelliforme lodd blume is a plant that has many benefits in health such as anticancer, antiinflammatory, analgesic and antihepatotoxic.
Typhonium flagelliforme induces apoptosis in cemss cells via activation of caspase9, parp cleavage and cytochrome c release. Leaf shape varies from simple elliptic to deeply divided, with blade length to 4. Uses, benefits, cures, side effects, nutrients in typhonium giganteum. Typhonium divaricatum is a green plant about one foot tall.
Natural products always offer alternate treatment therapies that are safe and effective. Typhonium flagelliforme inhibits the proliferation of murine. Pdf cytotoxicity effects of typhonium flagelliforme and. Typhonium flagelliforme or keladi tikus is a local plant known to. Typhonium flagelliforme inhibits cancer cell growth in vitro. Even though the potential use of bioactive compounds from t. In vitro culture plants of typhonium flagelliforme were found to decolorize a variety of dyes, including malachite green, red he 8b, methyl orange, reactive red 2, direct red 5b dr5b, red he 7b, golden yellow her, patent blue, and brilliant blue r bbr, to varying extents within 4 days. However, these treatments produced inefficient effects and low survival. Growth and yield response of rodent tuber typhonium. Pdf typhonium flagelliforme is a prominent plant candidate from aroid family. How typhonium giganteum is effective for various diseases is listed in repertory format. Gamma irradiation can be used to increase genetic variation. Typhonium flagelliforme inhibits cancer cell growth in. Its flower ends in a long filament resembling the tail of a mouse, hence its popular lay name.
Typhonium flagelliforme is an indigenous plant of malaysia and is. Typhonium flagelliforme have been reported to act as. The plant typhonium flagelliforme tf, commonly known as rodent tuber in malaysia, is often used as traditional. Based on the result of gcms, in the nbutanol extract of typhonium flagelliforme lodd. This page was last edited on 16 december 2019, at 17. Keladi tikus typhonium flagelliforme lodd blume is a plant that has many benefits in health such as anticancer, antiinflammatory, analgesic and. Antibacterial and antioxidant activity of keladi tikus. Various extracts prepared from either the roots, tubers, stems or leaves were tested for cytotoxic activity on murine p388 leukaemia cells using the mtt assay method. In silico screening of mutated kras inhibitors from. The enzymatic analysis of plant roots of aseptically raised plantlets performed before and after. Typhonium flagelliforme in world checklist of selected plant families. Pdf anticancerous effect of typhonium flagelliforme on. Anin vitro cytotoxicity screening of thetyphonium flagelliforme extracts indicated high cytotoxicity effect on human lung carcinoma nclh23 cells and human mammary gland carcinoma t47d cells, but the extracts were not active on human liver carcinoma hepg2 cells.
Typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh. However, there is no available information to address that tf affects murine leukemia cells in vitro and in vivo. These were murashige and skoog ms, nitsch and nitsch nn, gamborg b5 gb5 and white w of which ms medium was found to be the best medium for in vitro culture of t. Pages in category typhonium the following 4 pages are in this category, out of 4 total. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Homeopathy is a very unique system of medicine because the ingredients are used at levels generally understood to be nontoxic, with no negative side effects. Cytotoxic effect, assessed with mtt assays, measured the absorbance of formazan complex at 595 nm that equaled to the. Bap is a cytokinintype pgr that is effective in inducing the production and propagation of buds from bud eyes gunawan, 1987. Rodent tuber, keladi tikus, tu ban xia or lao shu yu botanical name. About typhonium typhonium plus alternative cancer treatment. Blume araceae is a herbal plant which grows up to 30cm in height. Typhonium plus contains ribosome in acting protein rip, anti oxidant, and anti curcumin. Together triggered cells may in turn produce mediators that stimulate and strengthen other cells of the immune system of the body to combat the. It is being used traditionally in malaysia to treat cancer.
Typhonium flagelliforme or keladi tikus is a local. Analysis of preliminary phytochemical screening of. Antiproliferation activity of tuber protein from typhonium flagelliforme lodd. Staminodes variable, spatulate to filamentous or variously reduced.
Pdf antibacterial and antioxidant activities of typhonium. Typhonium flagelliforme induces apoptosis in cemss cells. Studies on phytoremediation potentiality of typhonium. Oct 30, 2018 typhonium flagelliforme in world checklist of selected plant families. Its activation coupled with g0g1 phase cell cycle arrest. Typhonium plus complementary alternative cancer treatment. Isolation and identification nbutanol extract from keladi. Rodent tuber keladi tikus obat kanker pengobatan kanker.
All varieties of this plant produced a single inflorescence consisting of a spadix, surrounded by. Pdf typhonium flagelliforme inhibits cancer cell growth in. Typhonium flagelliforme rodent tuber is a herbal plant which grows up to 30cm in height. An in vitro culture system was developed for typhonium flagelliforme using buds from the rhizomes. Hence, the antileukemia effect of typhonium flagelliforme was investigated in vitro and in vivo leukemic model. In vitro propagation of typhonium flagelliforme lodd. The plant typhonium flagelliforme araceae, commonly known as the rodent tuber, is often included as an essential ingredient in various herbal remedies recommended for cancer therapies in malaysia. This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells.
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